For dissolution of cholesterol gallstones in selected patient with uncomplicated radiolucent gallstone disease: 8-10 mg/kg of body weight a day, divided into 2-3 doses usually taken with meals.
Prevention of gallstone formation in obese patients experiencing rapid weight loss: 300 mg twice a day. Continuous dose depending on the size and composition of the stone(s). Response should be monitored by ultrasonograms performed at 6 month intervals during the first year of therapy. After the complete dissolution, it is recommended that URSODE be continued for at least 3 months to promote dissolution of particles that are too small to image.